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An explanation for weak effects of Orlistat on duodenal lipolysis of liquid test meal. In vivo, the duodenal lipolysis of the liquid meal was only slightly decreased by Xsnical pellets and micronized Orlistat powder Table 4 ; , whereas a strong HPL inhibition was recorded in the duodenal samples 77%; Table 3 ; . An explanation for these paradoxical results was obtained on the performance of in vitro lipolysis of the test meals, with or without Orlistat. On the one hand, it was observed that the half-inhibition time of HPL was 5 min with both types of test meals and both forms of the drug Fig. 4, B and E, and Fig. 5, B and E ; . This value was found to be similar to that estimated from in vivo experiments 6.2 min; Fig. 3 ; . On the other hand, the variations in the lipolysis levels of the liquid and solid test meals with time were found to be strikingly different. When pancreatic juice or pure HPL was added to the meal-gastric juice mixture, the TGs of the liquid test meal were hydrolyzed to a large extent before the enzyme was significantly inhibited by Orlistat Figs. 4C and 5C ; . In contrast, no significant hydrolysis of the solid meal TGs occurred before the enzyme had been significantly inhibited by Orlistat Figs. 4F and 5F ; . The liquid meal TGs are a much better substrate for HPL than the solid meal TGs. It can therefore be concluded that the duodenal lipolysis of the liquid meal TGs is poorly reduced by Orlistat because the rate of TG hydrolysis by HPL is faster than the rate of HPL inhibition by Orlistat. With the solid meal, the opposite situation occurs, and Orlistat is an efficient inhibitor of duodenal lipolysis. No such problem was encountered in the case of gastric lipolysis because the rate of HGL inhibition by Orlistat is extremely fast half-inhibition time 1 min ; , and gastric lipolysis was always stopped.

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1. Berkow, Robert M.D., The Merck Manual of Diagnosis and Therapy, 14 Edition, Merck, Sharp & Dohme Research Lab., N.J., 1987, p. 808 2. Wald, Arnold, M.D.-Up To date Patient Information University of Pittsburgh Medical Center, June 2005 3. Bensow, Paul, B. M.D., McDermott, Walsh, M.D.-Textbook Of Medicine, 11 Edition, W. B. Saunders Co, Phil., 1963, pp. 883885 4. Berkow, Robert, M.D., The Merck Manual of Diagnosis and Therapy, 14 Edition, Merck, Sharp & Dohme Research Lab., N.J. 1987 5. Duenwald, Mary, New Remedies For a Frustrating Illness, But Do They Work? New York Times Science Section, 2005 6. Duenwald Mary, New Remedies For a Frustrating Illness, But Do They Work? New York Times Science Section, 2005 7. Ibid., Duenwald 8. Walther, David, S. D.C., -Synopsis-Applied Kinesiology 2nd Edition, System DC, Pueblo, CO, 2000, p. 494 9. Spencer, Alexander, P., Ph.D. & Mason, Elliott, B., Ph.D.-Human Anatomy and Physiology, 3rd Edition, Benjamin Cummings Publishing Co., 1983, p. 627 10. Guyton, Arthur, C., M.D., Textbook Of Medical Physiology, 3rd Edition, W.B. Saunders Co., Phil., 1966 11. Ibid., Spencer, Alexander, P. Ph.D., & Manson, Elliott, B., Ph.D. 12. Pfeiffer, Carl, C., Ph.D., M.D.-Mental and Elemental Nutrients, Keats Publishing, New Canaan, CT, 1975 13. Wald, Arnold, M.D. patient Information Irritable Bowel Syndrome, University of Pittsburgh, Medical Center, 2005 14. Murry, Robert, M.D., Ph.D., Granner, Daryl, M.D., Mayer, Peter, Ph.D., D ., Rodwell, Victor, Ph.D., Harper's Biochemistry, 21st Edition, Appleton & Lange Publishing , 1988, p. 610. 15. Schmitt, Walther, H. D. C., Correlation of Applied Kinesiology Muscle Testing Findings With Serum Immunologlobulin Levels for Food Allergies, International Journal of Neuroscience, Vol. 96, Nos. 34, 1988 16. Walther, David, S. D.C., Synopsis-Applied Kinesiology, 2nd Edition, System DC, Pueblo, CO, 2000, p. 390 17. Sandra Blakeslee, Complex and Hidden Brain in The Gut Makes Stomachs and Butterflies, New York Times, Science Times, Jan. 23, 1996, Section C1 18. Gallo, Fred, P., Ph.D., Energy Psychology, CRC Press, 1999 19. Walther, David, S., D.C., Synopsis-Applied Kinesiology, 2nd Edition, System DC, Pueblo, CO, 2000, p. 388 20. Sprieser, Paul, T., D.C. Adult Attention Deficit Disorder and Learning Disabilities, Collected Papers of International College of Applied Kinesiology Vol. 1, 20052006, Pages 193208 on CD page 221236.
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